Following on from our webinar ‘Non-Alcoholic Fatty Liver Disease and Nutrition’, we have pulled together some of the key resources and references discussed within the webinar, plus some additional ones on the topic. We have also included useful websites and social media accounts recommended to keep up to date on the subject. If you missed the live webinar, you can watch the recording
Download a PDF visual summary of the main webinar message.
REPORTS AND GUIDELINES
Reversing fatty liver disease with healthy lifestyle (2021), The Alpro Foundation. 16 page report written by a group of four clinicians, summarising the literature explaining the role of lifestyle in the development of fatty liver disease
Non-alcoholic fatty liver disease (NAFLD): assessment and management (2016), National Institute of Health and Care Excellence (NICE). NICE guidance covering the lifestyle changes and pharmacological treatments that can manage NAFLD
Preventing excess weight gain (2015), NICE. Guidelines from NICE for the prevention of weight gain
Obesity: identification, assessment and management (2014), NICE. Guidelines from NICE for obesity management
RESEARCH/STUDIES
A plant-based meal reduces postprandial oxidative and dicarbonyl stress in men with diabetes or obesity compared with an energy- and macronutrient-matched conventional meal in a randomized crossover study (2021), Malinska et al. Research highlighting the herapeutic potential of plant-based nutrition in improving the progression of complications in T2D and obese patients
Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH (2020), Hydes et al. Study supporting the evidence behind reducing saturated fat, refined carbohydrates, and red and processed meats in the diet, and increasing the consumption of plant-based foods
Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults (2020), Kahleova et al. Randomised trial looking into low-fat vegan diets and body weight, insulin resistance, postprandial metabolism, and lipid levels in overweight adults
Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance (2020), Sarabhaji et al. Study indicating that amount of ingested fat, rather than its composition, primarily determines the development of acute insulin resistance
Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease (2020), Ajatar S. J. Research into the natural history, risk stratification, and management of NAFLD
Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial (2019), Rosqvist et al. Study showing that saturated fatty acids increase liver fat vs dietary polyunsaturated fats prevent liver fat accumulation
Relation of total sugars, fructose and sucrose with incident type 2 diabetes (2017), Tsilas et al. Systematic review and meta-analysis looking into the association between fructose-containing sugars and type 2 diabetes
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance (2017), Alverez et al. A study finding that palm oil reduces insulin sensitivity
Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes (2015), Imamura F et al. Study finding that habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity
Non-alcoholic fatty liver disease and type 2 diabetes mellitus: The liver disease of our age? (2014), Gabor Firneisz. A review article discussing NAFLD in detail including the epidemiology of NAFLD and the relationship of NAFLD to different forms of diabetes
Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD) (2014), Chiu et. Systematic review looking into the effect of fructose on NAFLD, finding that isocaloric exchange of fructose for other carbohydrates does not induce NAFLD changes in healthy participants. The study did however, highlight that excess fructose intakes are of concern
Role of dietary fats in modulating cardiometabolic risk during moderate weight gain: a randomized double-blind overfeeding trial (LIPOGAIN study) (2014), Iggman et al. Study which found that eating muffins made with unsaturated fats were more beneficial compared to muffins made with saturated fats in terms of cardiometabolic responses
Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes: a randomised crossover study (2014), Kahleova et al. Study finding that eating two larger meals a day was beneficial for patients with type 2 diabetes compared to those eating six smaller meals
Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes (2011), Kahleova et al. Study showing that a calorie-restricted vegetarian diet had greater capacity to improve insulin sensitivity compared with a conventional diabetic diet over 24 weeks
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome (2007), Peterson KF et al. Research exploring whether insulin resistance in skeletal muscle promotes the development of atherogenic dyslipidemia
Mechanisms of Disease: hepatic steatosis in type 2 diabetes–pathogenesis and clinical relevance (2006), Roden at al. Study looking into the role of ectopic fat and lower insulin sensitivity
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes (2005), Peterson et al. Research highlighting that moderate weight loss leads to improvements in hyperglycaemia
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study (1999), Krssak et al. Study highlighting the link between lipid concentrations and whole body insulin sensitivity in non-diabetic, non-obese humans
PRACTICAL RESOURCES
Reversing Fatty Liver Disease with Healthy Lifestyle (2021), The Alpro Foundation. Video showing an interview with Prof. Massimiliano Ruscica and MSc. Paolo Dongiovanni about NAFLD
Vegetarian, vegan and plant-based diet: Food Fact Sheet (2021), The British Dietetic Association. Food fact sheet into plant-based dietary patterns
Non-alcohol related fatty liver disease (2018), British Liver Trust. Information leaflet giving an overview into NAFLD
Treating NAFLD with a healthy diet and physical activity (2021), British Liver Trust. Information leaflet focusing on lifestyle interventions for NAFLD
NHS weight loss plan (2019), NHS. 12 week weight loss plan developed under the supervision and advice of specialist dietitians from the British Dietetic Association
How Your Diet Can Impact Non-Alcoholic Fatty Liver Disease (NAFLD) (2018), City Dietitians. Article covering lifestyle factors around NAFLD
Non-Alcoholic Fatty Liver Disease (2018), The National Health Service. Information covering diagnosis and management, including lifestyle intervention for NAFLD
Weight loss, food fact sheet (2016), British Dietetic Association. Food fact sheet covering key aspects of losing weight
Brochures including NALFD At a Glance, NALFD Brochure, NAFLD Infographic and NAFLD Handout, The Liver Foundation. Various brochures from the American Liver Foundation
SOCIAL MEDIA
Alpro Foundation (Website) for The Alpro Foundation
@LiverTrust (Twitter), british_liver_trust (Instagram) and British Liver Trust (Website) for the British Liver Trust
@Liver4Life (Twitter), and Liver4Life (Website) for Liver4Life – UK National Charity
@livernorth (Twitter) for LIVErNORTH and LIVErNORTH (Website) for LIVErNORTH – National UK charity supporting liver patients and funding research
@liverUSA (Twitter), americanliver (Instagram) and American Liver Foundation (Website) for the American Liver Foundation
@bda_gastro (Twitter) for the British Dietetic Association’s Gastroenterology Specialist Group
