Semaglutide and Weight

Professor Giles Yeo

Tuesday 13 February 2024 20:00–21:00 GMT

Season 5


There has been much controversy surrounding the recent surge in demand and availability of the weight loss drug, Semaglutide, which is sold under the brand names Wegovy, Ozempic and Rybelsus.

The medication, originally developed for the treatment of type 2 diabetes, has recently been approved for use in the UK for weight management. Semaglutide is a GLP-1 receptor agonist, and has been suggested to be the most important breakthrough in obesity treatment to date, but what does the evidence say?

In this Journal Club session, we’ll discuss a recently published clinical trial paper investigating the results from 2 years follow-up of GLP-1 receptor agonist, semaglutide.

This session covers:

  • What GLP-1 is and its role in physiology
  • The effects of GLP-1 receptor agonist on weight change and food intake
  • Evidence for change in relationship with food, food choice and cravings
  • Other effects of GLP-1 on the body
  • How to evaluate data from a clinical trial and appreciate limitations

Watch this webinar to

Gain clear understanding of:
  • What is GLP-1 and its role in physiology?
  • Nutrient regulation of GLP-1
  • Effects of GLP-1 receptor agonist on weight change and food intake
  • Evidence for change in relationship with food, food choice and cravings
Be aware of:
  • Different ways of assessing food engagement
  • Other effects of GLP-1 on the body
Be able to:
  • Evaluate data from a clinical trial
  • Appreciate limitations in clinical studies

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Professor Giles Yeo

Expert speaker

Professor Giles Yeo
Professor of Molecular Neuroendocrinology, MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge


Giles Yeo is a Professor of Molecular Neuroendocrinology and programme leader at the MRC Metabolic Diseases Unit in Cambridge and his research currently focuses on the influence of genes on feeding behaviour & body-weight. He is a fellow of Wolfson College, and Honorary President of the British Dietetic Association.

Paper reference

Wharton, S, Batterham, RL, Bhatta, M, et al. Two-year effect of semaglutide 2.4 mg on control of eating in adults with overweight/obesity: STEP 5. Obesity (Silver Spring). 2023; 31(3): 703-715. doi: https://doi.org/10.1002/oby.23673

Dr Caroline Childs - Lecturer in Nutritional Sciences within Medicine at the University of Southampton

About Journal Club Chair, Dr Pippa Gibson RNutr PhD


Each Journal Club session is chaired by Dr Pippa Gibson.
Pippa gained her BSc from the University of Surrey, before returning to complete her PhD where she studied the role of vitamin D on the progression of paediatric liver disease. After graduating Pippa moved to King’s College London as a post-doctoral research associate investigating the role of interesterified fats on cardiometabolic health before moving into the gastrointestinal health team investigating the role of dietary compounds on constipation and functional bloating. Pippa left academia for industry and joined a contract catering company, Accent Catering, as Head of Nutrition, primarily working in nutrition education in schools to promote healthy messages across all ages. Pippa has recently moved the The British Nutrition Foundation as a Senior Nutrition Scientist. You can find some of Pippa’s work on the MyNutriWeb pages as she regularly contributes to the MyNutriWeb blogs.


Nutrition research reported in the media often highlights mixed or contradictory results between studies. So, as a nutrition professional, how can you ensure you use the strongest available evidence to inform your practice?


This webinar has been approved for CPD by the AfN

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